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| * '''Description:''' manganese [[ABC transporter]] (binding protein, lipoprotein) <br/><br/>
| | {{#bank: MntA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''mntA''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ytgA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || manganese [[ABC transporter]] (binding protein)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || manganese uptake
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU30770 mntA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=MntA MntA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=mntA mntA]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 33 kDa, 6.162
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 918 bp, 306 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[mntB]]'', ''[[menC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU30770 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU30770 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU30770 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:mntA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mntA_3145038_3145958_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mntA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU30770]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[ABC transporters]]}},
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| {{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[MntR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU30770
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| ===Phenotypes of a mutant ===
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| * essential according to [http://www.ncbi.nlm.nih.gov/pubmed/17114254 Kobayashi et al.], but a mutant has been constructed and studied by [http://www.ncbi.nlm.nih.gov/pubmed/10760146 Que and Helmann, 2000]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU30770&redirect=T BSU30770]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/mntABCD.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13851]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' bacterial solute-binding protein 9 family (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[ZnuA]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[MntB]]-([[MntC]]-[[MntD]])-[[MntA]] {{PubMed|10092453}}
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| * '''[[Localization]]:''' cell membrane (according to Swiss-Prot), extracellular lipoprotein (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU30770&redirect=T BSU30770]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O34385 O34385]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU30770]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[mntA]]-[[mntB]]-[[mntC]]-[[mntD]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mntA_3145038_3145958_-1 mntA] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| ** repressed at high Mn(II) concentrations ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12950915 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[MntR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12950915 PubMed]
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| * '''Additional information:'''
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| ** A [[ncRNA]] is predicted between ''[[mntA]]'' and ''[[menC]]'' {{PubMed|20525796}}
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 96 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]
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| =Your additional remarks=
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| =References=
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| <pubmed>10760146,10092453,,12950915,10760146,18957862 10760146 17114254,20525796 </pubmed>
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| [[Category:Protein-coding genes]]
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