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| * '''Description:''' [[cell division]] protein, membrane anchor for [[FtsZ]] <br/><br/>
| | {{#bank: FtsA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''ftsA''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''spoIIN ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[cell division]] protein
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || formation of Z-ring
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15280 ftsA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=FtsA FtsA]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 47 kDa, 5.094
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1320 bp, 440 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sbp]]'', ''[[ftsZ]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU15280 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU15280 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU15280 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ftsA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsA_1596474_1597796_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ftsA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15280]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell division]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigH regulon]]}},
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| {{SubtiWiki regulon|[[WalR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU15280
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| ===Phenotypes of a mutant ===
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| * cells become elongated {{PubMed|24218584}}
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| * the ''[[ftsA]]'' mutation is synthetically lethal with a ''[[sepF]]'' mutation {{PubMed|24218584}}
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|
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15280&redirect=T BSU15280]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ftsAZ.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10231]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' ftsA/mreB family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[FtsZ]]-[[FtsA]] {{PubMed|16159787}}
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| ** [[PlsX]]-[[FtsA]] {{PubMed|24224907}}
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| * '''[[Localization]]:'''
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| ** septal at the cell membrane {{PubMed|20566861}}
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| ** septal localization depends on the proton motive force {{PubMed|20566861}}
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|
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15280&redirect=T BSU15280]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P28264 P28264]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU15280]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[ftsA]]-[[ftsZ]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/1569582 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ftsA_1596474_1597796_1 ftsA] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/1569582 PubMed], [[SigH]] [http://www.ncbi.nlm.nih.gov/sites/entrez/1569582 PubMed]
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| * '''Regulation:'''
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| ** activated by [[WalR]] [http://www.ncbi.nlm.nih.gov/sites/entrez/10878122 PubMed]
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 205 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 422 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1A787 ( ''ftsA''::''cat''), {{PubMed|8071208}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A787&Search=1A787 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 19680248 </pubmed>
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| ==Original Publications==
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| <pubmed>16796675,12081956,16159787,11298280,18776011,9287012,1569582,10878122,7592498, 20566861 23036588 23701187 24218584 24224907 24316672 </pubmed>
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| [[Category:Protein-coding genes]]
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