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| * '''Description:''' repression of the hexuronate utilization operon (''[[uxaC]]-[[yjmB]]-[[yjmC]]-[[yjmD]]-[[uxuA]]-[[yjmF]]-[[exuT]]-[[exuR]]-[[uxaB]]-[[uxaA]]'') <br/><br/>
| | {{#bank: ExuR}} |
| {| align="right" border="1" cellpadding="2" | |
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''exuR''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yjmH ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor ([[LacI family]])
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of hexuronate utilization
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU12370 exuR]
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 37 kDa, 5.846
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 999 bp, 333 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[exuT]]'', ''[[uxaB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU12370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU12370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU12370 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:exuR_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=exuR_1308802_1309803_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:exuR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU12370]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[ExuR regulon]]}},
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| {{SubtiWiki regulon|[[SigE regulon]]}}
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| =The [[ExuR regulon]]:=
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| * ''[[uxaC]]-[[yjmB]]-[[yjmC]]-[[yjmD]]-[[uxuA]]-[[yjmF]]-[[exuT]]-[[exuR]]-[[uxaB]]-[[uxaA]]''
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| =The gene=
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|
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| === Basic information ===
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| * '''Locus tag:''' BSU12370
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|
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU12370&redirect=T BSU12370]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/uxaC-yjmBCD-uxuA-yjmF-exuTR-uxaBA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13211]
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|
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| === Additional information===
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|
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' [[LacI family]]
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:''' galacturonate acts as the molecular inducer [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU12370&redirect=T BSU12370]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q9JMQ1 Q9JMQ1]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU12370]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[uxaC]]-[[yjmB]]-[[yjmC]]-[[yjmD]]-[[uxuA]]-[[yjmF]]-[[exuT]]-[[exuR]]-[[uxaB]]-[[uxaA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| ** ''[[yjmC]]-[[yjmD]]-[[uxuA]]-[[yjmF]]-[[exuT]]-[[exuR]]-[[uxaB]]-[[uxaA]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=exuR_1308802_1309803_1 exuR] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigE]] {{PubMed|15699190}}
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| ** ''[[uxaC]]'': [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| ** ''[[yjmC]]'': [[SigE]] [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| * '''Regulation:'''
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| ** repressed by glucose ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]
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| ** induced by galacturonate ([[ExuR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[CcpA]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/10666464 PubMed2]
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| ** [[ExuR]]: reanscription repression in the absence of inducer [http://www.ncbi.nlm.nih.gov/sites/entrez/9882655 PubMed]
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| * '''Additional information:'''
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| ** number of protein molecules per cell (minimal medium with glucose and ammonium): 91 {{PubMed|24696501}}
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| ** number of protein molecules per cell (complex medium with amino acids, without glucose): 346 {{PubMed|24696501}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed> 9579062, 9882655, 10666464 </pubmed>
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| [[Category:Protein-coding genes]]
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