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| * '''Description:''' [[MarR/DUF24 family]] transcription repressor of the ''[[catD]]-[[catE]]'' operon <br/><br/>
| | {{#bank: CatR}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''catR''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvaP''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[MarR/DUF24 family]] transcription repressor
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| |style="background:#ABCDEF;" align="center"|'''Function''' || resistance against oxidative and electrophile stress
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33680 catR]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 9.887
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 708 bp, 236 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvaO]]'', ''[[yvaQ]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33680 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33680 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33680 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yvaP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yvaP_3457615_3457941_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:catR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33680]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transcription factors and their control]]}},
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| {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The [[CatR regulon]]:=
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| ''[[catD]]-[[catE]]''
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU33680
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| ===Phenotypes of a mutant ===
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| increased resistance to catechol and quinones {{PubMed|20639328}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33680&redirect=T BSU33680]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14071]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' [[MarR/DUF24 family]] transcription repressor of the'' [[catD]]-[[catE]]'' operon {{PubMed|20639328}}
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| * '''Protein family:''' [[MarR/DUF24 family]]
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| * '''Paralogous protein(s):''' [[YodB]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:''' in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of ''[[catD]]-[[catE]]'') {{PubMed|20639328}}
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33680&redirect=T BSU33680]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32238 O32238]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33680]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yvaP_3457615_3457941_1 catR] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Haike Antelmann]],University of Greifswald, Germany
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| =Your additional remarks=
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| =References=
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| =Reviews=
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| Antelmann H, Helmann JD.
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| Thiol-based redox switches and gene regulation.
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| Antioxid Redox Signal. 2011,14:1049-63.
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| {{PubMed|20626317}}
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| <pubmed>18282125</pubmed>
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| =Original Articles=
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| <pubmed> 20639328 </pubmed>
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| [[Category:Protein-coding genes]]
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