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| * '''Description:''' undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis <br/><br/>
| | {{#bank: UppS}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''uppS''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yluA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes {{PubMed|22904278}}
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| |style="background:#ABCDEF;" align="center"| '''Product''' || undecaprenyl pyrophosphate synthetase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || cell wall biosynthesis
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16530 uppS]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=UppS UppS]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 780 bp, 260 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[frr]]'', ''[[cdsA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU16530 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU16530 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU16530 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:uppS_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=uppS_1721214_1721996_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:uppS_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16530]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell wall synthesis]]}},
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| {{SubtiWiki category|[[biosynthesis of lipids]]}},
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| {{SubtiWiki category|[[essential genes]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU16530
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| ===Phenotypes of a mutant ===
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| * essential {{PubMed|22904278}}
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| * ''uppS'' is dispensable in wall-less L-forms {{PubMed|24704074}}
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| * the ''[[uppS86]]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin {{PubMed|22904278}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU16530&redirect=T BSU16530]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13408]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
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| * '''Protein family:''' UPP synthetase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU16530&redirect=T BSU16530]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?pdbId=1X09 1X09] (the protein from ''E. coli'', 49% identity, 77% similarity) {{PubMed|15788389}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O31751 O31751]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16530]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/2.5.1.31 2.5.1.31]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=uppS_1721214_1721996_1 uppS] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed> 22904278 23796923 15788389 23840410 24704074</pubmed>
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| [[Category:Protein-coding genes]]
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