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| * '''Description:''' succinate-semialdehyde dehydrogenase (NADP), general stress protein <br/><br/>
| | {{#bank: GabD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''gabD''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ycnH ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || succinate-semialdehyde dehydrogenase (NADP)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || utilization of gamma-amino butyric acid
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03910 gabD]
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 50 kDa, 4.763
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1386 bp, 462 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gabT]]'', ''[[glcU]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03910 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03910 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03910 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:gabD_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gabD_442950_444338_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:gabD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03910]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[utilization of amino acids]]}},
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| {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[GabR regulon]]}},
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| {{SubtiWiki regulon|[[SigB regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU03910
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| ===Phenotypes of a mutant ===
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| ** growth defect in the presence of gamma-aminobutyrate {{PubMed|24127574}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU03910&redirect=T BSU03910]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/gabTD.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12044]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):''' [[YfmT]], [[AldY]], [[YcbD]], [[GbsA]], [[DhaS]], [[IolA]], [[PutC]], [[RocA]], [[AldX]], [[YwdH]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU03910&redirect=T BSU03910]
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| * '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3RHH 3RHH] (from from ''Bacillus halodurans'' C-125 complexed with NADP, 36% identity, 68% similarity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P94428 P94428]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU03910]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[gabT]]-[[gabD]]'' {{PubMed|12123465}}
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| ** [[gabD]] {{PubMed|12123465}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gabD_442950_444338_1 gabD] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| ** ''[[gabT]]'': [[SigA]] {{PubMed|12123465}}
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| ** ''[[gabD]]'': [[SigB]] [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed]
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| * '''Regulation:'''
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| ** ''[[gabT]]'': expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate ([[GabR]]) {{PubMed|12123465}}
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| ** ''[[gabD]]'': induced by stress ([[SigB]]) [http://www.ncbi.nlm.nih.gov/pubmed/15805528 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[GabR]]: transcription activation {{PubMed|12123465}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Linc Sonenshein|Linc Sonenshein]], Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html Homepage]
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| =Your additional remarks=
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| =References=
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| <pubmed>15223311,12123465,,11544224 15805528, </pubmed>
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| [[Category:Protein-coding genes]]
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