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| * '''Description:''' copper transport protein, metallochaperone <br/><br/>
| | {{#bank: CopZ}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''copZ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvgY ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || copper transport protein, metallochaperone
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || resistance to copper
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33510 copZ]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CopZ CopZ]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=CopZ CopZ]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 7 kDa, 4.162
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 207 bp, 69 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[copA]]'', ''[[csoR]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33510 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33510 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33510 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yvgY_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=copZ_3443613_3443822_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:copZ_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33510]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transporters/ other]]}},
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| {{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
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| {{SubtiWiki category|[[resistance against toxic metals]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CsoR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU33510
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33510&redirect=T BSU33510]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14107]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):''' carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) {{PubMed|19746989}}
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[CopA]]-[[CopZ]], for the transfer of the Cu(I) cluster {{PubMed|19751213}}
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33510&redirect=T BSU33510]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2QIF 2QIF]
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32221 O32221]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33510]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[copZ]]-[[copA]]'' {{PubMed|12779235}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=copZ_3443613_3443822_-1 copZ] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|12779235}}
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| * '''Regulation:'''
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| ** induced by copper ([[CsoR]]) {{PubMed|18048925,12779235}}
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| * '''Regulatory mechanism:'''
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| ** [[CsoR]]: transcription repression {{PubMed|18048925}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 19824702 </pubmed>
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| ==Original publications==
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| <pubmed>18361527,11922674,12590580,14663075,12779235,12644235,18048925,19170606,14514665,14711369, 15212800 19170606 19746989 19751213 18419582 22370900 12238948 11980486 </pubmed>
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| [[Category:Protein-coding genes]]
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