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| * '''Description:''' translation initiation factor IF-3 <br/><br/>
| | {{#bank: InfC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''infC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| |style="background:#ABCDEF;" align="center"| '''Product''' || initiation factor IF-3
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| |style="background:#ABCDEF;" align="center"|'''Function''' || translation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28870 infC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 10.342
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 519 bp, 173 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[rpmI]]'', ''[[yscB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28870 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28870 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28870 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:infC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=infC_2952828_2953349_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:infC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28870]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[translation]]}},
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| {{SubtiWiki category|[[essential genes]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[RplT regulon]]}},
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| {{SubtiWiki regulon|[[stringent response]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU28870
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| ===Phenotypes of a mutant ===
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| essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28870&redirect=T BSU28870]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/infC-rpmI-rplT-ysdA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11944]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' IF-3 family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28870&redirect=T BSU28870]
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1TIF 1TIF] (N-terminal domain, Geobacillus stearothermophilus), [http://www.rcsb.org/pdb/explore.do?structureId=1TIG 1TIG] (C-terminal domain, Geobacillus stearothermophilus)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P55872 P55872]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28870]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[infC]]-[[rpmI]]-[[rplT]]-[[ysdA]]'' {{PubMed|17289755}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=infC_2952828_2953349_-1 infC] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|17289755}}
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| * '''Regulation:'''
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| ** [[RelA]] dependent downregulation (Class I) during stringent response {{PubMed|11948165}}
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| * '''Regulatory mechanism:'''
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| ** binding of [[RplT]] to a [[RNA switch]] in the ''[[infC]]'' leader region causes transcription termination {{PubMed|17289755}}
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| * '''Additional information:'''
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| ** expression of [[infC|IF3]] is uncoupled from that of [[rpmI|L35]] and [[rplT|L20]] by [[rny|RNase Y]]-dependent processing {{PubMed|21843271}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>17289755 11948165 21843271 7664745 21303765 23584454 </pubmed>
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| [[Category:Protein-coding genes]]
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