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| * '''Description:''' copper-transporting ATPase, resistance to copper <br/><br/>
| | {{#bank: CopA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''copA''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvgX ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || copper transporting ATPase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || copper export, detoxification
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33500 copA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CopA CopA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 85 kDa, 5.484
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2409 bp, 803 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[cadA]]'', ''[[copZ]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33500 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33500 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33500 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yvgX_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=copA_3441121_3443529_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:copA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33500]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transporters/ other]]}},
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| {{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
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| {{SubtiWiki category|[[resistance against toxic metals]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CsoR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU33500
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33500&redirect=T BSU33500]
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14106]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' ATP + H<sub>2</sub>O + Cu<sup>1+</sup>(In) = ADP + phosphate + Cu<sup>1+</sup>(Out) (according to Swiss-Prot)
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| * '''Protein family:''' Type IB subfamily (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| ** two N-terminal soluble domains, CopAa and CopAb, connected by a short linker
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[CopA]]-[[CopZ]], for the transfer of the Cu(I) cluster {{PubMed|19751213}}
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| * '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33500&redirect=T BSU33500]
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| * '''Structure:'''
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| ** [http://www.rcsb.org/pdb/explore.do?structureId=2RML 2RML] ( N-terminal soluble domain)
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| ** [http://www.pdb.org/pdb/explore/explore.do?structureId=4BBJ 4BBJ] (the protein from ''Legionella pneumophila'', 45% identity, 79% similarity) {{PubMed|24317491}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32220 O32220]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33500]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[copZ]]-[[copA]]'' {{PubMed|12779235}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=copA_3441121_3443529_-1 copA] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12779235}}
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| * '''Regulation:'''
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| ** induced by copper ([[CsoR]]) {{PubMed|18048925,12779235}}
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| * '''Regulatory mechanism:'''
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| ** [[CsoR]]: transcription repression {{PubMed|18048925}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[John Helmann]], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>19824702 23046649</pubmed>
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| ==Original publications==
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| <pubmed>19751213 11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369, 19378562 15212800 20233928 24317491 22531974,22077885</pubmed>
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| [[Category:Protein-coding genes]]
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