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| * '''Description:''' late competence gene required for processing and translocation of [[ComGC]], [[ComGD]], [[ComGE]] and [[ComGG]] {{PubMed|9723928}} <br/><br/>
| | {{#bank: ComC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''comC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || processing protease
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[genetic competence]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28070 comC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComC ComC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 9.843
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 744 bp, 248 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[spoIIB]]'', ''[[folC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28070 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28070 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28070 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:comC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comC_2864426_2865172_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:comC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28070]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[genetic competence]]}},
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| {{SubtiWiki category|[[protein secretion]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ComK regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU28070
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28070&redirect=T BSU28070]
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/comC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10323]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** processing and translocation of [[ComGC]], [[ComGD]], [[ComGE]] and [[ComGG]] {{PubMed|9723928}}
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| ** Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)
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| * '''Protein family:''' peptidase A24 family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[ComC]]-[[ComGC]] {{PubMed|9723928}}
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| ** [[ComC]]-[[ComGD]] {{PubMed|9723928}}
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| ** [[ComC]]-[[ComGE]] {{PubMed|9723928}}
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| ** [[ComC]]-[[ComGG]] {{PubMed|9723928}}
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| * '''[[Localization]]:'''
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| ** integral membrane protein {{PubMed|24164455}}
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| === Database entries ===
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| * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28070&redirect=T BSU28070]
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P15378 P15378]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU28070]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''comC'' {{PubMed|1694528}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comC_2864426_2865172_-1 comC] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|1694528}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| ** [[ComK]]: transcription activation {{PubMed|8196543}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 15083159 </pubmed>
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| ==Original publications==
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| <pubmed>9723928,16751195,7783624,2553669,1694528, 8196543 24164455</pubmed>
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| [[Category:Protein-coding genes]]
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