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| * '''Description:''' c-di-GMP degrading phosphodiesterase <br/><br/>
| | {{#bank: PdeH}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''pdeH''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yuxH, comB, yufA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || c-di-GMP degrading phosphodiesterase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || degradation of c-di-GMP
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31740 pdeH]
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 47 kDa, 5.36
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1227 bp, 409 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yuzC]]'', ''[[pncB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU31740 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU31740 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU31740 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yuxH_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yuxH_3258037_3259266_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:yuxH_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU31740]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[metabolism of signalling nucleotides]]}},
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| {{SubtiWiki category|[[motility and chemotaxis]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Spo0A regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU31740
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yuxH.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10377]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** degradation of c-di-GMP {{PubMed|23893111}}
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| * '''Protein family:''' comB family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| ** contains an EAL domain {{PubMed|22821967}}
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P14203 P14203]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU31740]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/3.1.3.71 3.1.3.71]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[pdeH]]'' {{PubMed|2507523}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yuxH_3258037_3259266_-1 pdeH] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|2507523}}
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| * '''Regulation:'''
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| ** repressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|14651647,15687200}}
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| * '''Regulatory mechanism:'''
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| ** [[Spo0A]]: transcription repression {{PubMed|14651647,15687200}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:''' GP1590 (kan) available in [[Jörg Stülke]]'s lab
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>14651647,15687200,2507523 22821967 23893111 </pubmed>
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| [[Category:Protein-coding genes]]
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