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| * '''Description:''' transcriptional regulator of anaerobic genes <br/><br/>
| | {{#bank: Fnr}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''fnr''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcription regulator (Crp family)
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of anaerobiosis, fermentation and overflow metabolism
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU37310 fnr]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=fnr fnr]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 27 kDa, 5.989
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 714 bp, 238 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywiC]]'', ''[[narK]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU37310 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU37310 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU37310 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:fnr_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fnr_3831512_3832228_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:fnr_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU37310]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[regulators of electron transport]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Fnr regulon]]}},
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| {{SubtiWiki regulon|[[NsrR regulon]]}},
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| {{SubtiWiki regulon|[[ResD regulon]]}}
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| =The [[Fnr regulon]]=
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU37310
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/narK-fnr.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11343]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Genes/ operons controlled by Fnr ===
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:''' contains an iron-sulfur cluster
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P46908 P46908]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU37310]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[narK]]-[[fnr]]'' {{PubMed|8846791}}
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| ** ''[[fnr]]'' {{PubMed|8846791}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=fnr_3831512_3832228_-1 fnr] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| ** ''[[narK]]'': [[SigA]] {{PubMed|8846791}}
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| ** ''[[fnr]]'': [[SigA]] {{PubMed|8846791}}
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| * '''Regulation:'''
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| ** ''[[narK]]'': expressed under anaerobic conditions ([[Fnr]]) {{PubMed|8846791,16428414}}
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| ** ''[[fnr]]'': expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10972836 PubMed]
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| ** induced by nitric oxide under anaerobic conditions ([[NsrR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16885456 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[ResD]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/10972836 PubMed]
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| ** [[NsrR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16885456 PubMed]
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| ** [[Fnr]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed]
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 23046954</pubmed>
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| ==The [[Fnr regulon]]==
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| <pubmed>16428414, </pubmed>
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| ==Other original publications==
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| <pubmed>8682783,,10972836,16885456,8846791,21068385 </pubmed>
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| [[Category:Protein-coding genes]]
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