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| * '''Description:''' imidazoleglycerol-phosphate dehydratase <br/><br/>
| | {{#bank: HisB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''hisB''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || imidazoleglycerol-phosphate dehydratase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of histidine
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34900 hisB]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=hisB hisB]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 5.598
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 582 bp, 194 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hisH]]'', ''[[hisD]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU34900 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU34900 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU34900 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:hisB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=hisB_3585690_3586274_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:hisB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34900]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[biosynthesis/ acquisition of amino acids]]}},
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| [[most abundant proteins]]
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU34900
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12598]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H<sub>2</sub>O (according to Swiss-Prot)
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| * '''Protein family:''' imidazoleglycerol-phosphate dehydratase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2AE8 2AE8] (from ''Staphylococcus aureus subsp. aureus n315 mutant'', 48% identity, 65% similarity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O34683 O34683]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU34900]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/4.2.1.19 4.2.1.19]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[hisZ]]-[[hisG]]-[[hisD]]-[[hisB]]-[[hisH]]-[[hisA]]-[[hisF]]-[[hisI]]'' {{PubMed|12107147}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=hisB_3585690_3586274_-1 hisB] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:''' repressed by casamino acids {{PubMed|12107147}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| ** belongs to the 100 [[most abundant proteins]] {{PubMed|15378759}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>12107147, 15378759</pubmed>
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| [[Category:Protein-coding genes]]
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