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| * '''Description:''' DNA 3'-5' helicase IV, stimulates transcription in an ATP-dependent manner by enhancing transcriptional cycling and elongation <br/><br/>
| | {{#bank: HelD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''helD''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' yvgS''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || DNA 3'-5' helicase IV
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[transcription]], [[DNA repair/ recombination]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33450 helD]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 89 kDa, 6.083
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2322 bp, 774 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[cysI]]'', ''[[yvgT]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33450 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33450 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33450 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yvgS_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=helD_3434327_3436651_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:helD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33450]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA repair/ recombination]]}},
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| {{SubtiWiki category|[[transcription]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU33450
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14101]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' UvrD subfamily (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** HelD interacts with the [[RNA polymerase]] core enzyme {{PubMed|24520113,21710567}}
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| * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:''' [http://pdb.org/pdb/explore/explore.do?structureId=3DMN 3DMN] (C-terminal domain of the protein from ''Lactobacillus plantarum'', 39% identity)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32215 O32215]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33450]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[helD]]'' {{PubMed|22383849}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=helD_3434327_3436651_-1 helD] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1A899 ( ''helD''::''erm''), available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A899&Search=1A899 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>24520113</pubmed>
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| <pubmed>11544244 21710567 </pubmed>
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| [[Category:Protein-coding genes]]
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