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| * '''Description:''' membrane fission protein, mediates membrane fission during [[sporulation]]<br/><br/>
| | {{#bank: FisB}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''fisB''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' yunB''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || membrane fission protein
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| |style="background:#ABCDEF;" align="center"|'''Function''' || release of the forespore into the mother cell cytoplasm
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU32350 fisB]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 27 kDa, 9.529
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 762 bp, 254 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[lytH]]'', ''[[yunC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU32350 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU32350 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU32350 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yunB_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yunB_3322463_3323227_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:yunB_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU32350]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[membrane dynamics]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigE regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU32350
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| ===Phenotypes of a mutant ===
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| * reduced sporulation efficiency (12 - 15%) {{PubMed|23388828}}
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yunB.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13976]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** mediates membrane fission during [[sporulation]] {{PubMed|23388828}}
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| ** binds cardiolipin {{PubMed|23388828}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cell membrane {{PubMed|23388828}}
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| ** forms dynamic foci which become immobilized at the site of membrane fission {{PubMed|23388828}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32131 O32131]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU32350]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''fisB'' {{PubMed|12662922}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yunB_3322463_3323227_-1 fisB] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigE]] {{PubMed|15699190,12662922}}
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| * '''Regulation:'''
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| ** expressed early during sporulation in the mother cell ([[SigE]]) {{PubMed|15699190,12662922}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 23518060 </pubmed>
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| ==Original publications==
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| <pubmed>12662922,15699190, 23388828 </pubmed>
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| [[Category:Protein-coding genes]]
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