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| * '''Description:''' regulator of [[FtsZ]] ([[TetR family]]), facilitates switch from medial to polar [[FtsZ]] ring placement during [[sporulation]] <br/><br/>
| | {{#bank: RefZ}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''refZ''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' yttP''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || regulator of [[FtsZ]]
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| |style="background:#ABCDEF;" align="center"|'''Function''' || relocalization of the [[FtsZ]] ring
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=RefZ RefZ]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 6.706
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 621 bp, 207 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hisJ]]'', ''[[ytsP]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU29630 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU29630 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU29630 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yttP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yttP_3032417_3033040_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:yttP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29630]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell division]]}},
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| {{SubtiWiki category|[[sporulation/ other]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[PhoP regulon]]}},
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| {{SubtiWiki regulon|[[Spo0A regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU29630
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yttP.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13927]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' facilitates switch from medial to polar [[FtsZ]] ring placement during [[sporulation]] {{PubMed|22730127}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| ** TetR-like DNA-binding helix-turn-helix domain at the N-terminus {{PubMed|22730127}}
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[RefZ]]-[[FtsZ]] {{PubMed|22730127}}
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| * '''[[Localization]]:'''
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| ** polar foci {{PubMed|22730127}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O34970 O34970]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29630]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''refZ'' {{PubMed|22383849}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yttP_3032417_3033040_-1 refZ] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** repressed by glucose (3.1-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]
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| ** induced early during [[sporulation]] ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
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| ** expressed under conditions of phosphate limitation ([[PhoP]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14762014 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[CcpA]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12850135 PubMed]
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| ** [[Spo0A]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/14651647 PubMed]
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| ** [[PhoP]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/14762014 PubMed]
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>24006471 </pubmed>
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| ==Original publications==
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| <pubmed>14651647,14762014,12850135 12850135, 22730127 22383849</pubmed>
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| [[Category:Protein-coding genes]]
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