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| * '''Description:''' transcriptional repressor of the ''[[fatR]]-[[yrhJ]]'' operon <br/><br/>
| | {{#bank: FatR}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''fatR''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yrhI, bscR ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor <br/>of the ''[[fatR]]-[[yrhJ]]'' operon (TetR family)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || unknown
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27170 fatR]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=FatR FatR]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 22 kDa, 5.621
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 582 bp, 194 aa
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yrhJ]]'', ''[[yrhH]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU27170 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU27170 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU27170 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yrhI_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bscR_2777070_2777654_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:fatR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27170]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[electron transport/ other]]}},
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| {{SubtiWiki category|[[lipid metabolism/ other]]}},
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| {{SubtiWiki category|[[transcription factors and their control]]}},
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| {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]}},
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| {{SubtiWiki category|[[phosphoproteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[FatR regulon]]}},
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| {{SubtiWiki regulon|[[SigM regulon]]}},
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| {{SubtiWiki regulon|[[SigW regulon]]}},
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| {{SubtiWiki regulon|[[SigX regulon]]}}
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|
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| =The [[FatR regulon]]:=
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| * ''[[fatR]]-[[yrhJ]]''
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU27170
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yrhIJ.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12298]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| ** phosphorylated by [[PtkA]] on Tyr-45, this results in displacement of FatR from the DNA {{PubMed|23939619}}
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[FatR]]-[[TkmA]] {{PubMed|23939619}}
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| ** [[FatR]]-[[PtkA]] {{PubMed|23939619}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O08335 O08335]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU27170]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[fatR]]-[[yrhJ]]'' {{PubMed|10917605}}
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| ** ''[[yrhH]]-[[fatR]]-[[yrhJ]]'' {{PubMed|18179421}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bscR_2777070_2777654_-1 fatR] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigM]] {{PubMed|18179421}}, [[SigW]] {{PubMed|12207695}}, [[SigX]] {{PubMed|9636707}}
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| * '''Regulation:'''
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| ** induced by unsaturated fatty acids ([[FatR]]) {{PubMed|11734890}}
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| ** expression is reduced in a [[SigV]] mutant {{PubMed|21926231}}
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| * '''Regulatory mechanism:'''
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| ** [[FatR]]: transcription repression {{PubMed|11734890}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>11734890,11574077,11377867,10917605,12207695,9636707 23939619 21926231</pubmed>
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| [[Category:Protein-coding genes]]
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