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| * '''Description:''' cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall <br/><br/>
| | {{#bank: SpoIIP}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''spoIIP''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || cell wall hydrolase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || dissolution of the septal cell wall
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU25530 spoIIP]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=SpoIIP SpoIIP]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 44 kDa, 6.852
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1203 bp, 401 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yqxA]]'', ''[[gpr]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU25530 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU25530 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU25530 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:spoIIP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoIIP_2633237_2634442_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:spoIIP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU25530]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell wall/ other]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigE regulon]]}},
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| {{SubtiWiki regulon|[[SigF regulon]]}},
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| [[Efp-dependent proteins]]
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU25530
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/spoIIP-yqxA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10439]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** removes the stem peptides from the cell wall and cleaves the cross-links between them {{PubMed|20159959}}
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| ** required for proper localization of [[SpoIIQ]] (together with [[SpoIID]]) {{PubMed|23834622}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:''' activity is stimulated by interaction with [[SpoIID]] {{PubMed|20159959}}
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[SpoIID]]-[[SpoIIP]] {{PubMed|20159959}}
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| ** [[SpoIIP]]-[[SpoIIM]] {{PubMed|17376078}}
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| * '''[[Localization]]:''' cell membrane {{PubMed|20159959}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P37968 P37968]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25530]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[spoIIP]]-[[yqxA]]'' {{PubMed|7836306}}, ''[[gpr]]-[[spoIIP]]'' {{PubMed|16497325}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoIIP_2633237_2634442_-1 spoIIP] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| ** ''[[spoIIP]]'': [[SigE]] {{PubMed|7836306}}
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| ** ''[[gpr]]'':[[SigF]] {{PubMed|16497325}}
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| * '''Regulation:''' expressed early during sporulation ([[SigE]],[[SigF]]) {{PubMed|16497325,7836306}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| ** [[translation]] is likely to require [[Efp]] due to the presence of several consecutive proline residues {{PubMed|23239624,23239623}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| == Reviews ==
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| <pubmed> 23944268 </pubmed>
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| == Original publications ==
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| <pubmed>16497325,17376078,15882622,11886548,15752199 , 20159959 20382772 23834622 23859254 </pubmed>
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| [[Category:Protein-coding genes]]
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