SpoVAC

• Description: mechanosensitive channel, essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2+) into developing spores, required for spore maturation
  
  

Gene name	spoVAC
Synonyms
Essential	no
Product	mechanosensitive channel
Function	spore maturation
Gene expression levels in SubtiExpress: spoVAC
Metabolic function and regulation of this protein in SubtiPathways: spoVAC
MW, pI	15 kDa, 9.461
Gene length, protein length	450 bp, 150 aa
Immediate neighbours	spoVAD, spoVAB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon

The gene

Basic information

• Locus tag: BSU23420

Database entries

• BsubCyc: BSU23420

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU23420

• Structure:

• UniProt: P40868

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoVAA-spoVAB-spoVAC-spoVAD-spoVAEB-spoVAEA-spoVAF-lysA PubMed

• Expression browser: spoVAC PubMed

• Sigma factor: SigG PubMed

• Regulation:
  • expressed late during sporulation in the forespore (SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Peter Setlow, University of Connecticut Health Center, USA

References

<pubmed>3114420,11751839,15451103,3926949,17158659,6432957,,7934830 15699190,1903432,8755877 22328679, 21398556 24666282 </pubmed>