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| * '''Description:''' cytochrome-c oxidase (subunit I) <br/><br/>
| | {{#bank: CtaD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''ctaD''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || cytochrome-c oxidase (subunit I)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || respiration
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14900 ctaD]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 68 kDa, 6.985
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1866 bp, 622 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ctaC]]'', ''[[ctaE]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14900 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14900 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14900 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ctaD_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctaD_1561569_1563437_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ctaD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14900]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[respiration]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Abh regulon]]}},
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| {{SubtiWiki regulon|[[AbrB regulon]]}},
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| {{SubtiWiki regulon|[[ResD regulon]]}},
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| [[Efp-dependent proteins]]
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU14900
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| ===Phenotypes of a mutant ===
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| essential according to [http://www.ncbi.nlm.nih.gov/pubmed/17114254 PubMed], non-essential according to {{PubMed|10551842}}
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ctaBCDEFG.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10216]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' 4 ferrocytochrome c + O<sub>2</sub> + 4 H<sup>+</sup> = 4 ferricytochrome c + 2 H<sub>2</sub>O (according to Swiss-Prot)
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| * '''Protein family:''' heme-copper respiratory oxidase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[QoxB]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):''' 2 heme A molecules, Cu(B) {{PubMed|10837475}}
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P24010 P24010]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14900]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/1.9.3.1 1.9.3.1]
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| === Additional information===
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| =Expression and regulation=
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| ** '''Operon:''' ''[[ctaB]]-[[ctaC]]-[[ctaD]]-[[ctaE]]-[[ctaF]]-[[ctaG]]'' {{PubMed|9829923}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctaD_1561569_1563437_1 ctaD] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** expressed under anaerobic conditions ([[ResD]]) {{PubMed|9829923}}
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| * '''Regulatory mechanism:'''
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| ** [[ResD]]: transcription activation {{PubMed|9829923}}
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| ** [[Abh]] and [[AbrB]]: synergistic transcription repression {{PubMed|20817675}}
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| * '''Additional information:'''
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| ** [[translation]] is likely to require [[Efp]] due to the presence of several consecutive proline residues {{PubMed|23239624,23239623}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>,1685007,10551842,9829923,17114254 20817675 10837475 </pubmed>
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| [[Category:Protein-coding genes]]
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