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| * '''Description:''' cytochrome-c oxidase (subunit II) <br/><br/>
| | {{#bank: CtaC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''ctaC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || cytochrome-c oxidase (subunit II)
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || [[respiration]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14890 ctaC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CtaC CtaC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 39 kDa, 8.635
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1068 bp, 356 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ctaB]]'', ''[[ctaD]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14890 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14890 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14890 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ctaC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctaC_1560466_1561536_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ctaC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14890]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[respiration]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[Abh regulon]]}},
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| {{SubtiWiki regulon|[[AbrB regulon]]}},
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[ResD regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU14890
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ctaBCDEFG.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10215]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' 4 ferrocytochrome c + O<sub>2</sub> + 4 H<sup>+</sup> = 4 ferricytochrome c + 2 H<sub>2</sub>O (according to Swiss-Prot)
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| * '''Protein family:''' cytochrome c oxidase subunit 2 family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):''' Cu(A) {{PubMed|10837475}}
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[Sco]]-[[CtaC]] {{PubMed|14766920}}
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| ** [[KinB]]-[[CtaC]] {{PubMed|23599347}}
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| ** part of a [[Respiratory complexes and supercomplexes|respiratory supercomplex]] {{PubMed|23880299}}
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| ** [[CtaC]]-[[CtaE]] {{PubMed|23880299}}
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| * '''[[Localization]]:'''
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| ** cell membrane {{PubMed|23880299}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P24011 P24011]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14890]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/1.9.3.1 1.9.3.1]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[ctaB]]-[[ctaC]]-[[ctaD]]-[[ctaE]]-[[ctaF]]-[[ctaG]]'' {{PubMed|9829923}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ctaC_1560466_1561536_1 ctaC] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| ** expressed under anaerobic conditions ([[ResD]]) {{PubMed|9829923}}
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| ** repressed by glucose (11-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed]
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| * '''Regulatory mechanism:'''
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| ** [[ResD]]: transcription activation {{PubMed|9829923}}
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| ** [[CcpA]]: transcription repression
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| ** [[Abh]] and [[AbrB]]: synergistic transcription repression {{PubMed|20817675}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>,9882689,1685007,10551842,9829923,12850135,23599347 20817675 23880299 10837475</pubmed>
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| [[Category:Protein-coding genes]]
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