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| * '''Description:''' thiol-disulfide oxidoreductase, with thioredoxin-like domain, required for the synthesis of the endospore peptidoglycan cortex <br/><br/>
| | {{#bank: StoA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''stoA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''spoIVH, ykvV''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || thiol-disulfide oxidoreductase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || spore cortex formation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13840 stoA]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=StoA StoA]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.297
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 495 bp, 165 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykvU]]'', ''[[zosA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13840 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13840 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13840 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ykvV_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=stoA_1450638_1451135_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:stoA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13840]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[sporulation proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigE regulon]]}},
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| {{SubtiWiki regulon|[[SigG regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU13840
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ykvUV.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13324]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' reduction of intramolecular disulfide bonds in [[SpoVD]] {{PubMed|19919673}}
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| * '''Protein family:''' thioredoxin domain (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** forespore envelope {{PubMed|19919673}}
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=3ERW 3ERW]
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O31687 O31687]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13840]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[ykvU]]-[[stoA]]'' {{PubMed|15292147}}
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| ** ''[[stoA]]'' {{PubMed|15292147}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=stoA_1450638_1451135_1 stoA] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| ** ''[[ykvU]]'': [[SigE]] {{PubMed|12662922}}
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| ** ''[[stoA]]'': [[SigG]] {{PubMed|15292147}}
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| * '''Regulation:'''
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| ** expressed during sporulation ([[SigE]], [[SigG]]) {{PubMed|12662922,15292147}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| ** A [[ncRNA]] is predicted between ''[[stoA]]'' and ''[[zosA]]'' {{PubMed|20525796}}
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| =Biological materials =
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| * '''Mutant:'''
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| ** 1S130 ( ''stoA''::''cat''), {{PubMed|15342593}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S130&Search=1S130 BGSC]
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| ** 1S131 ( ''stoA''::''tet''), {{PubMed|15342593}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S131&Search=1S131 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Lars Hederstedt]], University of Lund, Sweden [http://www.cob.lu.se/microbiology/heme.html Homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 19919674 </pubmed>
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| ==Original Publications==
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| <pubmed>,12662922,15292147,15342593, 19144642 19919673 20525796</pubmed>
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| [[Category:Protein-coding genes]]
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