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| * '''Description:''' DNA exonuclease <br/><br/>
| | {{#bank: SbcC}} |
| {| align="right" border="1" cellpadding="2" | |
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''sbcC''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yirY''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || DNA exonuclease
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| |style="background:#ABCDEF;" align="center"|'''Function''' || DNA inter-strand cross-link repair
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU10650 sbcC]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=SbcC SbcC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 128 kDa, 5.294
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 3390 bp, 1130 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sbcD]]'', ''[[hlpB]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU10650 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU10650 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU10650 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yirY_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sbcC_1144749_1148141_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:sbcC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU10650]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA repair/ recombination]]}},
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| {{SubtiWiki category|[[genetic competence]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[ComK regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU10650
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sbcD-yirY-yisB.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13088]
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| === Additional information===
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|
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' SbcC subfamily (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[SsbA]]-[[SbcC]] {{PubMed|21170359}}
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| * '''[[Localization]]:''' Nucleoid (Mid-cell) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O06714 O06714]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU10650]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[addB]]-[[addA]]-[[sbcD]]-[[sbcC]]-[[hlpB]]'' {{PubMed|22383849}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sbcC_1144749_1148141_1 sbcC] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| ** positive regulation by [[ComK]] {{PubMed|11948146}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** GP894 (''sbcCD''::''kan''), available in [[Stülke]] lab
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| ** 1A898 ( ''sbcC''::''cat''), {{PubMed|16780573}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A898&Search=1A898 BGSC]
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| [[Peter Graumann]], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed>19308706 22933559 </pubmed>
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| ==Original publications==
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| <pubmed>16780573,11948146, 16479537 22383849 21170359</pubmed>
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| [[Category:Protein-coding genes]]
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