PgcA: Difference between revisions
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* the inactivation of ''[[pgcA]]'' suppresses the poor and filametous growth of the ''[[yvcL]] [[zapA]]'' double mutant {{PubMed|24097947}} | * the inactivation of ''[[pgcA]]'' suppresses the poor and filametous growth of the ''[[yvcL]] [[zapA]]'' double mutant {{PubMed|24097947}} | ||
=== Database entries === | === Database entries === | ||
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU09310&redirect=T BSU09310] | |||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
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=== Database entries === | === Database entries === | ||
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU09310&redirect=T BSU09310] | |||
* '''Structure:''' | * '''Structure:''' | ||
Revision as of 13:17, 2 April 2014
- Description: alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)
| Gene name | pgcA |
| Synonyms | yhxB, gtaC, gtaE |
| Essential | no |
| Product | alpha-phosphoglucomutase |
| Function | interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate |
| Gene expression levels in SubtiExpress: pgcA | |
| Metabolic function and regulation of this protein in SubtiPathways: pgcA | |
| MW, pI | 62 kDa, 4.913 |
| Gene length, protein length | 1695 bp, 565 aa |
| Immediate neighbours | glpD, yhcY |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Categories containing this gene/protein
cell wall synthesis, lipid metabolism/ other, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU09310
Phenotypes of a mutant
- the inactivation of pgcA suppresses the poor and filametous growth of the yvcL zapA double mutant PubMed
Database entries
- BsubCyc: BSU09310
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)
- Protein family: phosphohexose mutase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Effectors of protein activity:
Database entries
- BsubCyc: BSU09310
- Structure:
- UniProt: P18159
- KEGG entry: [2]
- E.C. number: 5.4.2.2
Additional information
PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
<pubmed>20735481 </pubmed>
Original publications
<pubmed>,15175311,17726680 16493705, 15640167 17662947 22396664 24097947</pubmed>