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| * '''Description:''' uptake of succinate, fumurate, malate and oxaloacetate via proton symport <br/><br/>
| | {{#bank: DctP}} |
| {| align="right" border="1" cellpadding="2" | |
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''dctP''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ydbH, dctA ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || C4-dicarboxylate transport protein
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || uptake of succinate, fumurate, malate and oxaloacetate
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU04470 dctP]
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=DctP DctP]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=dctP dctP]'''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 45 kDa, 8.668
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1263 bp, 421 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dctR]]'', ''[[ydbI]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU04470 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU04470 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU04470 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:dctP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dctP_500166_501431_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:dctP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU04470]]
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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|
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[transporters/ other]]}},
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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|
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[FsrA regulon]]}}
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|
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU04470
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12075]
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| === Additional information===
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|
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** uptake of succinate, fumurate, malate and oxaloacetate via proton symport {{PubMed|20363944}}
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| ** acts as co-sensor for [[DctS]] {{PubMed|24375102}}
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| * '''Protein family:''' View classification (according to Swiss-Prot)
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| * '''Paralogous protein(s):''' [[GltP]], [[GltT]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''[[Domains]]:'''
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| * '''Modification:'''
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| * '''[[Cofactors]]:'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[DctB]]-[[DctS]]-[[DctP]], sensing complex {{PubMed|24375102}}
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| * '''[[Localization]]:'''
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| ** cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:''' [http://pdb.org/pdb/explore/explore.do?structureId=4KY0 4KY0] (the glutamate transporter of ''Thermococcus kodakarensis'', 31% identity, 71% similarity) {{PubMed|24013209}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P96603 P96603]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU04470]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[dctS]]-[[dctR]]-[[dctP]]'' {{PubMed|10708364}}
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| ** ''[[dctP]]'' {{PubMed|10708364}}
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|
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dctP_500166_501431_1 dctP] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:'''
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| ** ''[[dctP]]'': [[SigA]] {{PubMed|10708364}}
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| * '''Regulation:'''
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| ** repressed by glucose (6.2-fold) ([[CcpA]]) {{PubMed|12850135}}
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| ** part of the iron sparing response, strong down-regulation in a'' [[fur]]'' mutant ([[Fur]], [[FsrA]]) {{PubMed|22389480}}
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| * '''Regulatory mechanism:'''
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| ** [[CcpA]]: transcription repression {{PubMed|12850135}}
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| ** [[Fur]]: indirect effect via control of ''[[fsrA]]'' expression {{PubMed|22389480}}
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| ** [[FsrA]]: translation inhibition {{PubMed|22389480}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>12850135, 10708364 10627041, 12949159 20363944 22389480 22900538 24013209 24375102</pubmed>
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| [[Category:Protein-coding genes]]
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