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FrlB: Difference between revisions

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{{SubtiWiki category|[[utilization of nitrogen sources other than amino acids]]}},
{{SubtiWiki category|[[utilization of nitrogen sources other than amino acids]]}},
{{SubtiWiki category|[[membrane proteins]]}},
{{SubtiWiki category|[[membrane proteins]]}},
{{SubtiWiki category|[[phosphoproteins]]}}
{{SubtiWiki category|[[phosphoproteins]]}},
[[most abundant proteins]]


= This gene is a member of the following [[regulons]] =
= This gene is a member of the following [[regulons]] =
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=== Additional information===
=== Additional information===


=The protein=
=The protein=
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* '''Kinetic information:'''
* '''Kinetic information:'''


* '''Domains:'''  
* '''[[Domains]]:'''  


* '''Modification:'''
* '''Modification:'''
** phosphorylated on Arg-48 {{PubMed|22517742}}
** phosphorylated on Arg-48 {{PubMed|22517742}}


* '''Cofactor(s):'''
* '''[[Cofactors]]:'''


* '''Effectors of protein activity:'''
* '''Effectors of protein activity:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=frlB_3351110_3352096_-1 frlB] {{PubMed|22383849}}
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=frlB_3351110_3352096_-1 frlB] {{PubMed|22383849}}


* '''Sigma factor:'''  
* '''[[Sigma factor]]:'''  


* '''Regulation:'''  
* '''Regulation:'''  
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** the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] {{PubMed|21815947}}
** the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] {{PubMed|21815947}}
** the ''[[frlB]]-[[frlO]]-[[frlN]]-[[frlM]]-[[frlD]]'' operon is not expressed in a ''[[cshA]]'' mutant {{PubMed|23175651}}
** the ''[[frlB]]-[[frlO]]-[[frlN]]-[[frlM]]-[[frlD]]'' operon is not expressed in a ''[[cshA]]'' mutant {{PubMed|23175651}}
** belongs to the 100 [[most abundant proteins]] {{PubMed|15378759}}


=Biological materials =
=Biological materials =
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=References=
=References=
<pubmed>22517742 23175651 21815947 15556630,18083814,12618455, 21347729, 18763711, 21398478</pubmed>
<pubmed>22517742 23175651 21815947 15556630,18083814,12618455, 21347729, 18763711, 21398478 15378759</pubmed>


[[Category:Protein-coding genes]]
[[Category:Protein-coding genes]]

Revision as of 16:02, 5 March 2014

  • Description: fructoselysine-6-P-glycosidase

Gene name frlB
Synonyms yurP
Essential no
Product fructoselysine-6-P-glycosidase
Function metabolism of aminoacylated fructose
Gene expression levels in SubtiExpress: frlB
Metabolic function and regulation of this protein in SubtiPathways:
frlB
MW, pI 36 kDa, 5.442
Gene length, protein length 984 bp, 328 aa
Immediate neighbours frlO, yurQ
Sequences Protein DNA DNA_with_flanks
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed















Categories containing this gene/protein

utilization of specific carbon sources, utilization of nitrogen sources other than amino acids, membrane proteins, phosphoproteins, most abundant proteins

This gene is a member of the following regulons

CodY regulon, FrlR regulon

The gene

Basic information

  • Locus tag: BSU32610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
    • phosphorylated on Arg-48 PubMed
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • frlB: repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • frlB: induced in the presence of fructosamine (FrlR) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

<pubmed>22517742 23175651 21815947 15556630,18083814,12618455, 21347729, 18763711, 21398478 15378759</pubmed>