PbpH

• Description: class B penicillin-binding protein H, required for cell wall synthesis during cell elongation
  
  

Gene name	pbpH
Synonyms	ykuA
Essential	no
Product	penicillin-binding protein H
Function	formation of a rod-shaped peptidoglycan cell wall
Gene expression levels in SubtiExpress: pbpH
MW, pI	76 kDa, 8.888
Gene length, protein length	2055 bp, 685 aa
Immediate neighbours	ykwD, kinA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, membrane proteins

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU13980

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • required for cell wall synthesis during cell elongation PubMed
  • driver of MreB dynamics PubMed

• Protein family: transpeptidase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • part of the elongasome PubMed

• Localization:
  • cell membrane (according to Swiss-Prot)
  • localization depends on the availability of peptidoglyan precursors (lipid II) PubMed

Database entries

• Structure:

• UniProt: Q796K8

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: pbpH PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:
  • A ncRNA is predicted between ykwD and pbpH PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed> 12896990 20525796 21636744,21636745 20817675 23199363 23895585 </pubmed>