Epr

• Description: minor extracellular serine protease, involved in control of swarming motility PubMed
  
  

Gene name	epr
Synonyms	ipa-15r
Essential	no
Product	minor extracellular serine protease
Function	protein degradation
Gene expression levels in SubtiExpress: epr
MW, pI	69 kDa, 9.875
Gene length, protein length	1935 bp, 645 aa
Immediate neighbours	ywbA, sacX
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, proteolysis, motility and chemotaxis

This gene is a member of the following regulons

DegU regulon, ScoC regulon, SigD regulon, SinR regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU38400

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase S8 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed

Database entries

• Structure:

• UniProt: P16396

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: epr PubMed

• Expression browser: epr PubMed

• Sigma factor: SigD PubMed

• Regulation:
  • repressed by SinR PubMed
  • repressed during exponential growth (ScoC) PubMed

• Regulatory mechanism:
  • activation by DegU, not activated by DegU-P PubMed
  • SinR: transcription repressionPubMed
  • ScoC: transcription repression PubMed
  • Spo0A: prevents repression by SinR PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A1021 ( epr::tet), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

<pubmed>20735481 </pubmed>

Original publications

<pubmed>16923912,3142851 19416356 , 18957862, 19416356 11751842 23660663 24115457 </pubmed>