GerD: Difference between revisions
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* '''Description:''' required for clustering of germinant receptors in the spore inner membrane<br/><br/> | * '''Description:''' scaffold of the [[germinosome]], required for clustering of germinant receptors in the spore inner membrane<br/><br/> | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
* defective in [[germination]] in response to nutrients {{PubMed|24530795}} | |||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
=The protein= | =The protein= | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
* '''Domains:''' | * '''[[Domains]]:''' | ||
** has an N-terminal signal sequence and a signal for fixation to lipid {{PubMed|23335419}} | ** has an N-terminal signal sequence and a signal for fixation to lipid {{PubMed|23335419}} | ||
* '''Modification:''' | * '''Modification:''' | ||
* ''' | * '''[[Cofactors]]:''' | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** forms trimeric rope-like structures {{PubMed|24530795}} | |||
** [[GerD]] is part of the [[germinosome]] in the spore inner membrane {{PubMed|21696470}} | ** [[GerD]] is part of the [[germinosome]] in the spore inner membrane {{PubMed|21696470}} | ||
** [[GerD]]-[[Lgt]] to fix [[GerD]] to diacylglycerol in the membrane {{PubMed|22493018}} | ** [[GerD]]-[[Lgt]] to fix [[GerD]] to diacylglycerol in the membrane {{PubMed|22493018}} | ||
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=== Database entries === | === Database entries === | ||
* '''Structure:''' | * '''Structure:''' [http://pdb.org/pdb/explore/explore.do?structureId=4O8W 4O8W] {{PubMed|24530795}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/P16450 P16450] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P16450 P16450] | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gerD_158515_159072_-1 gerD] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gerD_158515_159072_-1 gerD] {{PubMed|22383849}} | ||
* '''Sigma factor:''' [[SigF]] {{PubMed|15699190}}, [[SigG]] {{PubMed|1906867,15699190}} | * '''[[Sigma factor]]:''' [[SigF]] {{PubMed|15699190}}, [[SigG]] {{PubMed|1906867,15699190}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
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=References= | =References= | ||
<pubmed>1906867,19332816,17122337, 21725007,18556788, 19332816 2517635 21696470 22327596 22493018 23335419 23749970 21398556</pubmed> | <pubmed>1906867,19332816,17122337, 21725007,18556788, 19332816 2517635 21696470 22327596 22493018 23335419 23749970 21398556 24530795 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:29, 18 February 2014
- Description: scaffold of the germinosome, required for clustering of germinant receptors in the spore inner membrane
| Gene name | gerD |
| Synonyms | |
| Essential | no |
| Product | lipoprotein |
| Function | germination |
| Gene expression levels in SubtiExpress: gerD | |
| Interactions involving this protein in SubtInteract: GerD | |
| MW, pI | 20 kDa, 4.862 |
| Gene length, protein length | 555 bp, 185 aa |
| Immediate neighbours | salA, kbaA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Categories containing this gene/protein
germination, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01550
Phenotypes of a mutant
- defective in germination in response to nutrients PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: required for clustering of germinant receptors in the spore inner membrane PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
Database entries
- UniProt: P16450
- KEGG entry: [3]
- E.C. number:
Additional information
- 3,500 molecules are present per spore PubMed
Expression and regulation
- Regulation:
- expression level depends on sporulation conditions (medim composition, temperature) PubMed
- Regulatory mechanism:
- Additional information:
- 3,500 molecules are present per spore PubMed
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody: available in Anne Moir lab
Labs working on this gene/protein
Anne Moir, University of Sheffield, UK
Your additional remarks
References
<pubmed>1906867,19332816,17122337, 21725007,18556788, 19332816 2517635 21696470 22327596 22493018 23335419 23749970 21398556 24530795 </pubmed>