MntA

• Description: manganese ABC transporter (binding protein, lipoprotein)
  
  

Gene name	mntA
Synonyms	ytgA
Essential	no
Product	manganese ABC transporter (binding protein)
Function	manganese uptake
Gene expression levels in SubtiExpress: mntA
Interactions involving this protein in SubtInteract: MntA
Metabolic function and regulation of this protein in SubtiPathways: mntA
MW, pI	33 kDa, 6.162
Gene length, protein length	918 bp, 306 aa
Immediate neighbours	mntB, menC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)

This gene is a member of the following regulons

MntR regulon

The gene

Basic information

• Locus tag: BSU30770

Phenotypes of a mutant

• essential according to Kobayashi et al., but a mutant has been constructed and studied by Que and Helmann, 2000

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 9 family (according to Swiss-Prot)

• Paralogous protein(s): ZnuA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • MntB-(MntC-MntD)-MntA PubMed

• Localization: cell membrane (according to Swiss-Prot), extracellular lipoprotein (signal peptide) PubMed

Database entries

• Structure:

• UniProt: O34385

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mntA-mntB-mntC-mntD PubMed

• Expression browser: mntA PubMed

• Sigma factor:

• Regulation:
  • repressed at high Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism:
  • MntR: transcription repression PubMed

• Additional information:
  • A ncRNA is predicted between mntA and menC PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

<pubmed>10760146,10092453,,12950915,10760146,18957862 10760146 17114254,20525796 </pubmed>