DppE

• Description: dipeptide ABC transporter (dipeptide-binding protein)
  
  

Gene name	dppE
Synonyms	dciAE
Essential	no
Product	dipeptide ABC transporter (dipeptide-binding protein)
Function	uptake of dipeptides
Gene expression levels in SubtiExpress: dppE
Interactions involving this protein in SubtInteract: DppE
Metabolic function and regulation of this protein in SubtiPathways: dppE
MW, pI	62 kDa, 5.523
Gene length, protein length	1647 bp, 549 aa
Immediate neighbours	dppD, ykfA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, utilization of nitrogen sources other than amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon

The gene

Basic information

• Locus tag: BSU12960

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 5 family (according to Swiss-Prot)

• Paralogous protein(s): OppA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (DppD-YkfD)-(DppB-DppC)-DppE PubMed

• Localization: attached to the cell membrane (via DppB-DppC) PubMed

Database entries

• Structure:

• UniProt: P26906

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: dppA-dppB-dppC-dppD-dppE PubMed

• Expression browser: dppE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant: GP1110 (spc), available in Stülke lab
  • 1A737 ( dppE::kan), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>12618455,10092453,1766371,,7783641,1766371,18763711, </pubmed>