CotT

• Description: spore coat protein (inner)
  
  

Gene name	cotT
Synonyms
Essential	no
Product	spore coat protein (inner)
Function	resistance of the spore
Gene expression levels in SubtiExpress: cotT
MW, pI	12 kDa, 9.466
Gene length, protein length	321 bp, 107 aa
Immediate neighbours	ctaO, pdaC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

SigK regulon, GerE regulon, SigE regulon, SpoIIID regulon

The gene

Basic information

• Locus tag: BSU12090

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • inner spore coat, localization depends on SafA PubMed

Database entries

• Structure:

• UniProt: P11863

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cotT PubMed

• Expression browser: cotT PubMed

• Sigma factor: SigK PubMed, SigE PubMed

• Regulation:
  • expressed during sporulation in the mother cell (SigE, SigK, GerE, SpoIIID) PubMed

• Regulatory mechanism:
  • SpoIIID: transcription activation PubMed
  • GerE: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1S108 ( cotT::cat), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Arthur Aronson, Purdue University, West Lafayette, USA homepage

References

Reviews

<pubmed>23202530</pubmed>

Original publications

<pubmed>10714992,1917883,2546006,15699190, 15383836 19933362 22171814 </pubmed>