BrxA: Difference between revisions
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* '''Protein family:''' scpA family (according to Swiss-Prot) | * '''Protein family:''' scpA family (according to Swiss-Prot) | ||
* '''Paralogous protein(s):''' [[ | * '''Paralogous protein(s):''' [[BrxB]] | ||
=== Extended information on the protein === | === Extended information on the protein === | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
* '''Domains:''' contains an CxC redox motif [http://www.ncbi.nlm.nih.gov/pubmed/20308541] | * '''[[Domains]]:''' contains an CxC redox motif [http://www.ncbi.nlm.nih.gov/pubmed/20308541] | ||
* '''Modification:''' | * '''Modification:''' | ||
** S-bacillithiolation upon hypochlorite stress on Cys-53 {{PubMed|21749987}} | ** S-bacillithiolation upon hypochlorite stress on Cys-53 {{PubMed|21749987}} | ||
* ''' | * '''[[Cofactors]]:''' | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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=Expression and regulation= | =Expression and regulation= | ||
* '''Operon:''' '' | * '''Operon:''' ''brxA'' (according to [http://dbtbs.hgc.jp/COG/prom/yphP.html DBTBS]) | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yphP_2300221_2300655_-1 yphP] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yphP_2300221_2300655_-1 yphP] {{PubMed|22383849}} | ||
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=Your additional remarks= | =Your additional remarks= | ||
[[YpdA]], [[ | [[YpdA]], [[BrxA]], [[BrxB]] and [[YtxJ]] co-occur in those species predicted to synthesize bacillithiol. | ||
=References= | =References= | ||
<pubmed> 22938038,19653655 20308541 21749987</pubmed> | <pubmed> 22938038,19653655 20308541 21749987 24313874 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:56, 13 December 2013
- Description: disulfide isomerase, bacilliredoxin
| Gene name | brxA |
| Synonyms | yphP |
| Essential | no |
| Product | disulfide isomerase, bacilliredoxin |
| Function | de-bacillithiolation of S-bacillithiolated OhrR and MetE |
| Gene expression levels in SubtiExpress: yphP | |
| MW, pI | 15 kDa, 4.619 |
| Gene length, protein length | 432 bp, 144 aa |
| Immediate neighbours | ypiP, ilvD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Categories containing this gene/protein
resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU21860
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: scpA family (according to Swiss-Prot)
- Paralogous protein(s): BrxB
Extended information on the protein
- Kinetic information:
- Modification:
- S-bacillithiolation upon hypochlorite stress on Cys-53 PubMed
- Effectors of protein activity:
Database entries
- UniProt: P54170
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Operon: brxA (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
YpdA, BrxA, BrxB and YtxJ co-occur in those species predicted to synthesize bacillithiol.
References
<pubmed> 22938038,19653655 20308541 21749987 24313874 </pubmed>