BrxA: Difference between revisions
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* '''Description:''' disulfide isomerase, | * '''Description:''' disulfide isomerase, bacilliredoxin <br/><br/> | ||
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
|'' | |''brxA'' | ||
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' '' | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' yphP'' | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || disulfide isomerase, | |style="background:#ABCDEF;" align="center"| '''Product''' || disulfide isomerase, bacilliredoxin | ||
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|style="background:#ABCDEF;" align="center"|'''Function''' || | |style="background:#ABCDEF;" align="center"|'''Function''' || de-bacillithiolation of S-bacillithiolated [[OhrR]] and [[MetE]] | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21860 yphP] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU21860 yphP] | ||
Revision as of 18:41, 13 December 2013
- Description: disulfide isomerase, bacilliredoxin
| Gene name | brxA |
| Synonyms | yphP |
| Essential | no |
| Product | disulfide isomerase, bacilliredoxin |
| Function | de-bacillithiolation of S-bacillithiolated OhrR and MetE |
| Gene expression levels in SubtiExpress: yphP | |
| MW, pI | 15 kDa, 4.619 |
| Gene length, protein length | 432 bp, 144 aa |
| Immediate neighbours | ypiP, ilvD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Categories containing this gene/protein
poorly characterized/ putative enzymes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU21860
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: scpA family (according to Swiss-Prot)
- Paralogous protein(s): yqiW
Extended information on the protein
- Kinetic information:
- Domains: contains an CxC redox motif [3]
- Modification:
- S-bacillithiolation upon hypochlorite stress on Cys-53 PubMed
- Cofactor(s):
- Effectors of protein activity:
Database entries
- UniProt: P54170
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Operon: yphP (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
YpdA, YqiW, YphP and YtxJ co-occur in those species predicted to synthesize bacillithiol.
References
<pubmed> 22938038,19653655 20308541 21749987</pubmed>