ComX: Difference between revisions
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
* the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[ | * the mutation suppresses the mucoid phenotype of ''[[motA]]'' or ''[[motB]]'' mutants due to loss of [[DegU]] phosphorylation and concomitant reduced expression of the ''[[capB]]-[[capC]]-[[capA]]-[[capE]]'' operon {{PubMed|24296669}} | ||
=== Database entries === | === Database entries === | ||
Revision as of 20:18, 4 December 2013
- Description: competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin
| Gene name | comX |
| Synonyms | |
| Essential | no |
| Product | competence pheromone precursor |
| Function | quorum sensing |
| Gene expression levels in SubtiExpress: comX | |
| Interactions involving this protein in SubtInteract: ComX | |
| MW, pI | 6 kDa, 4.358 |
| Gene length, protein length | 165 bp, 55 aa |
| Immediate neighbours | comP, comQ |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Categories containing this gene/protein
genetic competence, quorum sensing
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31700
Phenotypes of a mutant
- the mutation suppresses the mucoid phenotype of motA or motB mutants due to loss of DegU phosphorylation and concomitant reduced expression of the capB-capC-capA-capE operon PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization:
- secreted (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P45453
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
The ComX --> surfactin signaling pathway is an example for paracrine signaling in bacteria
References
Reviews
<pubmed> 22024380 </pubmed>
Original publications
<pubmed>16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685, 1715859 22878193 24296669 22511326,21636272 </pubmed>