Map

• Description: methionine aminopeptidase
  
  

Gene name	map
Synonyms	mapA
Essential	yes PubMed
Product	methionine aminopeptidase
Function	removal of N-terminal methionine from nascent proteins
Gene expression levels in SubtiExpress: map
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Protein secretion
MW, pI	27 kDa, 6.393
Gene length, protein length	744 bp, 248 aa
Immediate neighbours	adk, ybzG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, protein modification, essential genes

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU01380

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides (according to Swiss-Prot)

• Protein family: peptidase M24A family (according to Swiss-Prot)

• Paralogous protein(s): YflG

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • Map-RplQ PubMed
  • Map-RplW PubMed
  • Map competes with peptide deformylase (DefA), the first enzyme to act on nascent chains, for binding sites at the ribosomal tunnel exit PubMed

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2MAT (from Escherichia coli, 46% identity, 65% similarity) PubMed

• UniProt: P19994

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: map PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information: strongly expressed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>16207374,8635744,23770820, </pubmed>