SunS

• Description: sublancin S-glycosyltransferase
  
  

Gene name	yolJ
Synonyms
Essential	no
Product	sublancin S-glycosyltransferase
Function	biosynthesis of the antimicrobial peptide sublancin
Gene expression levels in SubtiExpress: sunS
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	49 kDa, 5.33
Gene length, protein length	1266 bp, 422 aa
Immediate neighbours	bdbB, bdbA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

SP-beta prophage, membrane proteins, protein modification, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

Abh regulon, AbrB regulon, Rok regulon, YvrHb regulon

The gene

Basic information

• Locus tag: BSU21450

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • selectively modifies Cys22 in a 56-amino acid peptide substrate SunA and can accept a variety of NDP-sugars PubMed

• Protein family: EngA subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O31986

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sunT-bdbA-sunS-bdbB PubMed

• Expression browser: sunS PubMed

• Sigma factor:

• Regulation:
  • repressed by Rok PubMed

• Regulatory mechanism:
  • activated by YvrHb PubMed
  • Rok: transcription repression PubMed
  • AbrB: transcription repressionPubMed
  • Abh: transcription activation PubMed

• Additional information:
  • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>15743949 21196935,20817675,21910430 21815947</pubmed>