GerKA

• Description: nutrient receptor
  
  

Gene name	gerKA
Synonyms
Essential	no
Product	nutrient receptor
Function	germination response to the combination of glucose, fructose, aspartate, and KCl
Gene expression levels in SubtiExpress: gerKA
Interactions involving this protein in SubtInteract: GerKA
MW, pI	60 kDa, 5.206
Gene length, protein length	1632 bp, 544 aa
Immediate neighbours	gerKD, gerKC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

germination, membrane proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon

The gene

Basic information

• Locus tag: BSU03700

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: gerABKA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • contains multiple membrane-spanning domains PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • GerKA-GerKB-GerKC (tentative receptor complex) PubMed
  • GerKA is part of the germinosome in the spore inner membrane PubMed

• Localization:
  • outer surface of the inner spore membrane PubMed

Database entries

• Structure:

• UniProt: P49939

• KEGG entry: [3]

• E.C. number:

Additional information

• 700 molecules are present per spore PubMed

Expression and regulation

• Operon: gerKA-gerKC-gerKB (according to DBTBS)

• Expression browser: gerKA PubMed

• Sigma factor: SigG PubMed

• Regulation:
  • expressed during sporulation (SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription repression PubMed

• Additional information:
  • 700 molecules are present per spore PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>16707705,16352818, 21696470 23335419 23396907 22343299,16740944, 23749970</pubmed>