EpsH: Difference between revisions
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{{SubtiWiki regulon|[[AbrB regulon]]}}, | {{SubtiWiki regulon|[[AbrB regulon]]}}, | ||
{{SubtiWiki regulon|[[EAR riboswitch]]}}, | {{SubtiWiki regulon|[[EAR riboswitch]]}}, | ||
{{SubtiWiki regulon|[[RemA regulon]]}}, | |||
{{SubtiWiki regulon|[[SinR regulon]]}} | {{SubtiWiki regulon|[[SinR regulon]]}} | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
** [[SinR]]: transcription | ** [[SinR]]: transcription anti-activation (prevents binding of [[RemA]]) {{PubMed|23646920}} | ||
** [[RemA]]: transcription activation {{PubMed|23646920}} | |||
** [[AbrB]]: transcription repression {{PubMed|20817675}} | ** [[AbrB]]: transcription repression {{PubMed|20817675}} | ||
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<pubmed>20374491 20230605 </pubmed> | <pubmed>20374491 20230605 </pubmed> | ||
===Other original publications=== | ===Other original publications=== | ||
<pubmed>23012477 15661000,16430695,18047568,11572999 ,15083514 18647168 20817675 21856853 21815947</pubmed> | <pubmed>23012477 15661000,16430695,18047568,11572999 ,15083514 18647168 20817675 21856853 21815947 23646920</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:25, 24 May 2013
- Description: extracellular polysaccharide synthesis
| Gene name | epsH |
| Synonyms | yveR |
| Essential | no |
| Product | unknown |
| Function | biofilm formation |
| Gene expression levels in SubtiExpress: epsH | |
| Regulation of this protein in SubtiPathways: Biofilm | |
| MW, pI | 39 kDa, 5.788 |
| Gene length, protein length | 1032 bp, 344 aa |
| Immediate neighbours | epsI, epsG |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Categories containing this gene/protein
This gene is a member of the following regulons
AbrB regulon, EAR riboswitch, RemA regulon, SinR regulon
The gene
Basic information
- Locus tag: BSU34300
Phenotypes of a mutant
- altered cell death pattern in colonies PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: glycosyltransferase 2 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P71057
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
- induction by sequestration of SinR by SinI or SlrA PubMed
- the epsA-epsB-epsC-epsD-epsE-epsF-epsG-epsH-epsI-epsJ-epsK-epsL-epsM-epsN-epsO operon is not expressed in a ymdB mutant PubMed
- the amount of the mRNA is substantially decreased upon depletion of RNase Y (this is likely due to the increased stability of the sinR mRNA) PubMed
- the EAR riboswitch (eps-associated RNA switch) located between epsB and epsC mediates processive antitermination and allows expression of the long eps operon PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Richard Losick, Harvard Univ., Cambridge, USA homepage
Your additional remarks
References
Reviews
<pubmed>20735481 </pubmed>
Original publications
The EAR RNA switch
<pubmed>20374491 20230605 </pubmed>
Other original publications
<pubmed>23012477 15661000,16430695,18047568,11572999 ,15083514 18647168 20817675 21856853 21815947 23646920</pubmed>