Revision as of 14:43, 16 May 2013

Description: glycerol-3-phosphate cytidylyltransferase

Gene name	tagD
Synonyms
Essential	yes PubMed
Product	glycerol-3-phosphate cytidylyltransferase
Function	biosynthesis of teichoic acid
*Gene expression levels in SubtiExpress*: tagD
MW, pI	15 kDa, 5.672
Gene length, protein length	387 bp, 129 aa
Immediate neighbours	tagE, tagA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

PhoP regulon, WalR regulon

The gene

Basic information

Locus tag: BSU35740

Phenotypes of a mutant

essential PubMed

Database entries

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity: CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol (according to Swiss-Prot)

Protein family: cytidylyltransferase family (according to Swiss-Prot)

Paralogous protein(s):

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions:
- TagD-TagD PubMed

Localization:
- cytoplasm (according to Swiss-Prot)

Database entries

Structure: 1N1D (complex with CDP-glycerol) PubMed, 1COZ

UniProt: P27623

KEGG entry: [3]

E.C. number: 2.7.7.39

Additional information

Expression and regulation

Operon: tagD-tagE-tagF PubMed

Expression browser: tagD PubMed

Sigma factor: SigA PubMed

Regulation:
- repressed by phosphate (PhoP) PubMed

Regulatory mechanism:
- PhoP: transcription repression PubMed
- WalR: transcription activation PubMed

Additional information:
- The mRNA has a long 5' leader region. This may indicate RNA-based regulation PubMed

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

Your additional remarks

References

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