Revision as of 11:25, 14 May 2013

Description: CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase

Gene name	tagF
Synonyms	rodC
Essential	yes PubMed
Product	CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase
Function	biosynthesis of teichoic acid
*Gene expression levels in SubtiExpress*: tagF
MW, pI	87 kDa, 9.4
Gene length, protein length	2238 bp, 746 aa
Immediate neighbours	tagG, tagE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes, membrane proteins

This gene is a member of the following regulons

PhoP regulon, WalR regulon

The gene

Basic information

Locus tag: BSU35720

Phenotypes of a mutant

essential PubMed

Database entries

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity: CDP-glycerol + (glycerophosphate)(n) = CMP + (glycerophosphate)(n+1) (according to Swiss-Prot)

Protein family: CDP-glycerol glycerophosphotransferase family (according to Swiss-Prot)

Paralogous protein(s):

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions:

Localization:
- membrane associated PubMed

Database entries

Structure:

UniProt: P13485

KEGG entry: [3]

E.C. number: 2.7.8.12

Additional information

Expression and regulation

Operon: tagD-tagE-tagF PubMed

Expression browser: tagF PubMed

Sigma factor: SigA PubMed

Regulation:
- repressed by phosphate (PhoP) PubMed
- strongly repressed in response to glucose starvation in M9 medium PubMed

Regulatory mechanism:
- PhoP: transcription repression PubMed
- WalR: transcription activation PubMed

Additional information:

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed <pubmed>18156271,16141206 2507871 ,12637499,1712357,9457886,18763711, 19520862 7581998 12950927 15547257 </pubmed>

@@ Line 22: / Line 22: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[tagG]]'', ''[[tagE]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35720 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35720 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35720 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35720 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35720 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35720 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:tagF_context.gif]]