Revision as of 10:07, 14 May 2013

Description: cytochrome-c oxidase (subunit I)

Gene name	ctaD
Synonyms
Essential	no
Product	cytochrome-c oxidase (subunit I)
Function	respiration
*Gene expression levels in SubtiExpress*: ctaD
MW, pI	68 kDa, 6.985
Gene length, protein length	1866 bp, 622 aa
Immediate neighbours	ctaC, ctaE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance PubMed

Categories containing this gene/protein

respiration, membrane proteins

This gene is a member of the following regulons

Abh regulon, AbrB regulon, ResD regulon, Efp-dependent proteins

The gene

Basic information

Locus tag: BSU14900

Phenotypes of a mutant

essential according to PubMed, non-essential according to PubMed

Database entries

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity: 4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O (according to Swiss-Prot)

Protein family: heme-copper respiratory oxidase family (according to Swiss-Prot)

Paralogous protein(s): QoxB

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions:

Localization:
- cell membrane (according to Swiss-Prot)

Database entries

Structure:

UniProt: P24010

KEGG entry: [3]

E.C. number: 1.9.3.1

Additional information

Expression and regulation

- Operon: ctaB-ctaC-ctaD-ctaE-ctaF-ctaG PubMed

Expression browser: ctaD PubMed

Sigma factor:

Regulation:
- expressed under anaerobic conditions (ResD) PubMed

Regulatory mechanism:
- ResD: transcription activation PubMed
- Abh and AbrB: synergistic transcription repression PubMed

Additional information:
- translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed <pubmed>,1685007,10551842,9829923,17114254</pubmed>

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 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ctaC]]'', ''[[ctaE]]''
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-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14900 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14900 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14900 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14900 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14900 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14900 DNA_with_flanks]
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