MtrB: Difference between revisions
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of tryptophan biosynthesis<br/>(and translation) attenuation in the trp operon;<br/>repression of the folate operon | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of tryptophan biosynthesis<br/>(and translation) attenuation in the trp operon;<br/>repression of the folate operon | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22770 mtrB] | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/MtrB TRAP] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/MtrB TRAP] | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hepS]]'', ''[[folE]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hepS]]'', ''[[folE]]'' | ||
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| | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU22770 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU22770 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU22770 Advanced_DNA] | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:mtrB_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:mtrB_context.gif]] | ||
Revision as of 13:09, 13 May 2013
- Description: tryptophan operon RNA-binding attenuation protein (TRAP), controls the RNA switch in front of genes involved in biosynthesis and acquisition of tryptophan
| Gene name | mtrB |
| Synonyms | |
| Essential | no |
| Product | tryptophan operon RNA-binding attenuation protein (TRAP) |
| Function | regulation of tryptophan biosynthesis (and translation) attenuation in the trp operon; repression of the folate operon |
| Gene expression levels in SubtiExpress: mtrB | |
| Interactions involving this protein in SubtInteract: TRAP | |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp, Folate | |
| MW, pI | 8 kDa, 7.333 |
| Gene length, protein length | 225 bp, 75 aa |
| Immediate neighbours | hepS, folE |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, transcription factors and their control, RNA binding regulators
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22770
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: prpD family (according to Swiss-Prot)
- Paralogous protein(s):
Genes controlled by MtrB
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- binding of tryptophan results RNA binding and thus in transcription termination
Database entries
- UniProt: P19466
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
<pubmed>19385727, 16285852, 15063849 </pubmed>
Original Publications
<pubmed> 22970197 19033375, 17881743 10660627 10714985 12963367 14702295 16879415 17114058 17114263 11805104,7525975,10735881,15262953,14976255,8647825,18334255,10499579,7715723,8932308,11214184,15743934,7515880,9242649,7759487,15050822,14687568,9245598,9765233,11914485,15099736,7678334,8643393,15588817,16738132,1551827,17555767,7544009,11786553,11566976,2123343,11557884,12133840,16784236,10369778,7715723 10499579 11566976 7515880, 21097886 21984911 </pubmed>