Revision as of 15:56, 7 August 2012

Description: copper transport protein, metallochaperone

Gene name	copZ
Synonyms	yvgY
Essential	no
Product	copper transport protein, metallochaperone
Function	resistance to copper
*Gene expression levels in SubtiExpress*: copZ
*Interactions involving this protein in SubtInteract*: CopZ
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	7 kDa, 4.162
Gene length, protein length	207 bp, 69 aa
Immediate neighbours	copA, csoR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance PubMed

Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), resistance against toxic metals

This gene is a member of the following regulons

CsoR regulon

The gene

Basic information

Locus tag: BSU33510

Phenotypes of a mutant

Database entries

DBTBS entry: no entry

SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity:

Protein family:

Paralogous protein(s):

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s): carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) PubMed

Effectors of protein activity:

Interactions:
- CopA-CopZ, for the transfer of the Cu(I) cluster PubMed

Localization: cytoplasm (according to Swiss-Prot)

Database entries

Structure: 2QIF

UniProt: O32221

KEGG entry: [2]

E.C. number:

Additional information

Expression and regulation

Operon: copZ-copA PubMed

Expression browser: copZ PubMed

Sigma factor: SigA PubMed
Regulation:
- induced by copper (CsoR) PubMed

Regulatory mechanism:
- CsoR: transcription repression PubMed

Additional information:

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Reviews

Original publications

@@ Line 13: / Line 13: @@
 |-
 |style="background:#ABCDEF;" align="center"|'''Function''' || resistance to copper
+|-
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU33510 copZ]
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/CopZ CopZ]