TagD

• Description: glycerol-3-phosphate cytidylyltransferase
  
  

Gene name	tagD
Synonyms
Essential	yes PubMed
Product	glycerol-3-phosphate cytidylyltransferase
Function	biosynthesis of teichoic acid
MW, pI	15 kDa, 5.672
Gene length, protein length	387 bp, 129 aa
Immediate neighbours	tagE, tagA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

PhoP regulon, WalR regulon

The gene

Basic information

• Locus tag: BSU35740

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol (according to Swiss-Prot)

• Protein family: cytidylyltransferase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • TagD-TagD PubMed

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1N1D (complex with CDP-glycerol) PubMed, 1COZ

• UniProt: P27623

• KEGG entry: [3]

• E.C. number: 2.7.7.39

Expression and regulation

• Operon: tagD-tagE-tagF PubMed

• Expression browser: tagD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by phosphate (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription repression PubMed
  • WalR: transcription activation PubMed

• Additional information:
  • The mRNA has a long 5' leader region. This may indicate RNA-based regulation PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>9683503,9457886,11673441,10508782,2507871,12950927, 7581998 20525796</pubmed>