DivIC

• Description: cell-division initiation protein (septum formation), component of septosome (with DivIB)
  
  

Gene name	divIC
Synonyms
Essential	yes PubMed
Product	cell-division protein
Function	septum formation
Interactions involving this protein in SubtInteract: DivIC
MW, pI	14 kDa, 9.968
Gene length, protein length	375 bp, 125 aa
Immediate neighbours	yabQ, yabR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell division, sporulation proteins, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes, membrane proteins

This gene is a member of the following regulons

SigE regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU00620

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: stabilizes FtsL against RasP cleavage PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • DivIC-FtsL PubMed
  • PbpB-DivIB-(FtsL-DivIC)2 PubMed, as part of the divisome

• Localization: membrane bound PubMed

Database entries

• Structure:

• UniProt: P37471

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • yabM-yabN-yabO-yabP-yabQ-divIC-yabR PubMed
  • yabP-yabQ-divIC-yabR PubMed
  • divIC-yabR PubMed

• Expression browser: divIC PubMed

• Sigma factor:
  • yabM: unknown
  • yabP: SigE PubMed
  • divIC: SigM PubMed, SigX PubMed, SigW PubMed

• Regulation: expressed during sporulation (SigE) PubMed and under stress conditions

• Regulatory mechanism:

• Additional information: there are about 50,000 molecules of DivIC per cell PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>18179421,16936019,10217758,9720875,8113187,10323866,9426141,10852898,10844672,11283287 , 11994149, 20644139</pubmed> Additional publications: PubMed