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m moved LytR to TagU: 21964069
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* '''Description:''' negative regulator for ''[[lytA]]-[[lytB]]-[[lytC]]'' and ''[[lytR]]'' expression <br/><br/>
* '''Description:''' phosphotransferase, attaches teichoic acid, teichuronic acid, or acidic capsular polysaccharide to cell wall peptidoglycan via phosphodiester linkage to N-acteylmuramic acid <br/><br/>


{| align="right" border="1" cellpadding="2"  
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
|-
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || negative regulator for ''[[lytA]]-[[lytB]]-[[lytC]]'' and ''[[lytR]]'' expression
|style="background:#ABCDEF;" align="center"| '''Product''' || phosphotransferase, responsible for attachment of anionic polymers to peptidoglycan
|-
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of cell separation and autolysis
|style="background:#ABCDEF;" align="center"|'''Function''' || transfer of anionic cell wall polymers from lipid-linked precursors to peptidoglycan
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/TagU TagU]
|-
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 9.527   
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 9.527   
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===Phenotypes of a mutant ===
===Phenotypes of a mutant ===
* a ''[[tagU]]'' mutant has no phenoype, the triple ''[[tagT]] [[tagU]] [[tagV]]'' mutant is unable to grow under normal conditions {{PubMed|21964069}}


=== Database entries ===
=== Database entries ===
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=== Additional information===
=== Additional information===




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* '''Catalyzed reaction/ biological activity:'''  
* '''Catalyzed reaction/ biological activity:'''  


* '''Protein family:''' lytR/cpsA/psr regulatory protein family (according to Swiss-Prot)
* '''Protein family:''' LytR-Cps2a-Psr family {{PubMed|19099556}}


* '''Paralogous protein(s):'''
* '''Paralogous protein(s):''' [[TagT]], [[TagV]]


=== Extended information on the protein ===
=== Extended information on the protein ===
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* '''Modification:'''
* '''Modification:'''


* '''Cofactor(s):'''
* '''Cofactor(s):''' Mg(2+) {{PubMed|21964069}}


* '''Effectors of protein activity:'''
* '''Effectors of protein activity:'''


* '''Interactions:'''
* '''[[SubtInteract|Interactions]]:'''  
** [[MreB]]-[[TagU]] {{PubMed|21964069}}


* '''Localization:''' cell membrane (according to Swiss-Prot)
* '''[[Localization]]:'''
** cytoplasmic membrane (with extracytoplasmic catalaytic domain) {{PubMed|21964069}}


=== Database entries ===
=== Database entries ===


* '''Structure:'''
* '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3MEJ 3MEJ] ([[TagT]], 36% identity, 69% similarity)


* '''UniProt:''' [http://www.uniprot.org/uniprot/Q02115 Q02115]
* '''UniProt:''' [http://www.uniprot.org/uniprot/Q02115 Q02115]
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=References=
=References=


<pubmed>9636707,1357079 , </pubmed>
<pubmed>9636707,1357079 , 19099556 21964069 </pubmed>


[[Category:Protein-coding genes]]
[[Category:Protein-coding genes]]

Revision as of 10:14, 30 October 2011

  • Description: phosphotransferase, attaches teichoic acid, teichuronic acid, or acidic capsular polysaccharide to cell wall peptidoglycan via phosphodiester linkage to N-acteylmuramic acid

Gene name lytR
Synonyms
Essential no
Product phosphotransferase, responsible for attachment of anionic polymers to peptidoglycan
Function transfer of anionic cell wall polymers from lipid-linked precursors to peptidoglycan
Interactions involving this protein in SubtInteract: TagU
MW, pI 34 kDa, 9.527
Gene length, protein length 918 bp, 306 aa
Immediate neighbours lytA, mnaA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell wall degradation/ turnover, transcription factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

LytR regulon, SigX regulon

The LytR regulon:

The gene

Basic information

  • Locus tag: BSU35650

Phenotypes of a mutant

  • a tagU mutant has no phenoype, the triple tagT tagU tagV mutant is unable to grow under normal conditions PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: LytR-Cps2a-Psr family PubMed

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 3MEJ (TagT, 36% identity, 69% similarity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

<pubmed>9636707,1357079 , 19099556 21964069 </pubmed>

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