LexA: Difference between revisions
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* '''Description:''' transcriptional repressor of the SOS regulon | ---- | ||
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=[http://ucozisit.co.cc UNDER COSTRUCTION, PLEASE SEE THIS POST IN RESERVE COPY]= | |||
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=[http://ucozisit.co.cc CLICK HERE]= | |||
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* '''Description:''' transcriptional repressor of the SOS regulon <br/><br/> | |||
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of DNA damage repair | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of DNA damage repair | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: | |colspan="2" style="background:#FAF8CC;" align="center"| '''Function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phosphorelay.html Phosphorelay]''' | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 22 kDa, 5.155 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 22 kDa, 5.155 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fosB]]'', ''[[yneA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[fosB]]'', ''[[yneA]]'' | ||
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13669]+-newId sequences] | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13669&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' | ||
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|colspan="2" | '''Genetic context''' | |colspan="2" | '''Genetic context''' <br/> [[Image:lexA_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | |||
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__TOC__ | __TOC__ | ||
<br/><br/><br/><br/><br/><br/> | |||
=The gene= | =The gene= | ||
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=References= | =References= | ||
<pubmed>8899710, 9045831 9555905 8969214, 1657879,,16267290 11532142 11551506 16549676 </pubmed> | |||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 23:28, 23 November 2010
- Description: transcriptional repressor of the SOS regulon <br/><br/>
| Gene name | lexA |
| Synonyms | dinR |
| Essential | no |
| Product | transcriptional repressor of the SOS regulon |
| Function | regulation of DNA damage repair |
| Function and regulation of this protein in SubtiPathways: <br/>Phosphorelay | |
| MW, pI | 22 kDa, 5.155 |
| Gene length, protein length | 615 bp, 205 aa |
| Immediate neighbours | fosB, yneA |
| Get the DNA and protein sequences <br/> (Barbe et al., 2009) | |
Genetic context <br/> 
<div align="right"> <small>This image was kindly provided by SubtiList</small></div> | |
<br/><br/><br/><br/><br/><br/>
The gene
Basic information
- Locus tag: BSU17850
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Represses uvrB, dinB, dinC, recA genes and itself by binding to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (according to Swiss-Prot)
- Protein family: peptidase S24 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- UniProt: P31080
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
<pubmed>8899710, 9045831 9555905 8969214, 1657879,,16267290 11532142 11551506 16549676 </pubmed>