Revision as of 11:37, 11 June 2009

Description: sublancin 168 lantibiotic antimicrobial precursor peptide

Gene name	sunA
Synonyms	yolG
Essential	no
Product	sublancin 168 lantibiotic antimicrobial precursor peptide
Function	antimicrobial peptide
MW, pI	5 kDa, 7.963
Gene length, protein length	168 bp, 56 aa
Immediate neighbours	sunT, sunI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

Locus tag: BSU21480

Phenotypes of a mutant

Database entries

DBTBS entry: [1]

SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

Catalyzed reaction/ biological activity:

Protein family: IPP isomerase type 2 family (according to Swiss-Prot)

Paralogous protein(s):

Extended information on the protein

Kinetic information:

Domains:

Modification:

Cofactor(s):

Effectors of protein activity:

Interactions:

Localization: cell membrane (according to Swiss-Prot)

Database entries

Structure:

Swiss prot entry: P68577

KEGG entry: [3]

E.C. number:

Additional information

Expression and regulation

Operon: sunA

Sigma factor:

Regulation:
- repressed during logrithmic growth (AbrB) PubMed

Regulatory mechanism: activated by YvrHb PubMed, repressed by AbrB PubMed, activated by Abh PubMed
- AbrB: transcription repression PubMed
- AbrB: transcription repression PubMed
- AbrB: transcription repression PubMed

Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

Mutant:

Expression vector:

lacZ fusion:

GFP fusion:

two-hybrid system:

Antibody:

Labs working on this gene/protein

Your additional remarks

References

Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed

@@ Line 1: / Line 1: @@
-#REDIRECT [[SkfB]]
+* '''Description:''' sublancin 168 lantibiotic antimicrobial precursor peptide <br/><br/>
+{| align="right" border="1" cellpadding="2"
+|-
+|style="background:#ABCDEF;" align="center"|'''Gene name'''
+|''sunA''
+|-
+|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yolG ''
+|-
+|style="background:#ABCDEF;" align="center"| '''Essential''' || no
+|-
+|style="background:#ABCDEF;" align="center"| '''Product''' || sublancin 168 lantibiotic antimicrobial precursor peptide
+|-
+|style="background:#ABCDEF;" align="center"|'''Function''' || antimicrobial peptide
+|-
+|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 5 kDa, 7.963
+|-
+|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 168 bp, 56 aa
+|-
+|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sunT]]'', ''[[sunI]]''
+|-
+|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14066&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
+|-
+|colspan="2" | '''Genetic context''' <br/> [[Image:sunA_context.gif]]
+ <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
+|-
+|}
+__TOC__
+<br/><br/>
+=The gene=
+=== Basic information ===
+* '''Locus tag:''' BSU21480
+===Phenotypes of a mutant ===
+=== Database entries ===
+* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunA.html]
+* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12682]
+=== Additional information===
+=The protein=
+=== Basic information/ Evolution ===
+* '''Catalyzed reaction/ biological activity:'''
+* '''Protein family:''' IPP isomerase type 2 family (according to Swiss-Prot)
+* '''Paralogous protein(s):'''
+=== Extended information on the protein ===
+* '''Kinetic information:'''
+* '''Domains:'''
+* '''Modification:'''
+* '''Cofactor(s):'''
+* '''Effectors of protein activity:'''
+* '''Interactions:'''
+* '''Localization:''' cell membrane (according to Swiss-Prot)
+=== Database entries ===
+* '''Structure:'''
+* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P68577 P68577]
+* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU21480]
+* '''E.C. number:'''
+=== Additional information===
+=Expression and regulation=
+* '''Operon:''' ''sunA''
+* '''[[Sigma factor]]:'''
+* '''Regulation:'''
+** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17720793 PubMed]
+* '''Regulatory mechanism:''' activated by [[YvrHb]]  [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed], repressed by [[AbrB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19465659 PubMed], activated by [[Abh]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19465659 PubMed]
+** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
+** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15687200,17720793 PubMed]
+** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/17720793 PubMed]
+* '''Additional information:'''  the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
+=Biological materials =
+* '''Mutant:'''
+* '''Expression vector:'''
+* '''lacZ fusion:'''
+* '''GFP fusion:'''
+* '''two-hybrid system:'''
+* '''Antibody:'''
+=Labs working on this gene/protein=
+=Your additional remarks=
+=References=
+<pubmed>16306698, 19465659   </pubmed>
+# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]