T-box

The T-box element is an RNA switch that controls genes involved in amino acid metabolism.

In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.

Complete list of genes controlled by T-box elements

• Induction by alanine limitation
  • alaS

• Induction by aspartate limitation
  • hisS-aspS

• Induction by cysteine limitation
  • cysE-cysS-mrnC-yacO-yacP

• Induction by glycine limitation
  • glyA, glyQ-glyS

• Induction by histidine limitation
  • hisS-aspS

• Induction by isoleucine limitation
  • ileS, ilvB-ilvH-ilvC-leuA-leuA-leuC-leuD

• Induction by leucine limitation
  • leuS, ilvB-ilvH-ilvC-leuA-leuA-leuC-leuD, yvbW

• Induction by phenyalanine limitation
  • pheS-pheT

• Induction by proline limitation
  • proB-proA, proI

• Induction by serine limitation
  • serS

• Induction by threonine limitation
  • thrS, thrZ-ywhA

• Induction by tryptophan limitation
  • rtpA-ycbK, trpS

• Induction by tyrosine limitation
  • tyrS, tyrZ

• Induction by valine limitation
  • valS, ilvB-ilvH-ilvC-leuA-leuA-leuC-leuD

Structure of a T-box ribowsitch

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Reviews on T-box regulation

<pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903 24816551</pubmed>

See also:

• RNA switch